Bioactive Small Molecules
Cayman Chemical ANTIBODY BPTES 1mg
An allosteric inhibitor of GLS1 (IC50 = 3.3 μM); selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase; decreases glutaminase activity and reduces proliferation of aerobic P493 cells; induces cell death, increases the production of ROS, and reduces ATP levels in hypoxic P493 cells; decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with UK 5099 and/or etomoxir; reduces tumor volume in a P493 lymphoma mouse xenograft model at 12.5 mg/kg
Medchemexpress LLC Flavin adenine dinucleotide | 146-14-5 | 98.9% | 100 MG
Flavin adenine dinucleotide (FAD) is a redox cofactor, specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism. This product is the analytical standard of Flavin adenine dinucleotide and is intended for research and analytical applications.
- Analytical standard of flavin adenine dinucleotide.
- Intended for research and analytical applications.
- Functions as a redox cofactor.
- Involved in important enzymatic reactions in metabolism.
Medchemexpress LLC PD-L1 inhibitory peptide TFA | 1983.29 | 50MG
PD-L1 inhibitory peptide TFA is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). It binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells, making it promising for cancer research.
- Targets programmed cell death ligand 1 (PD-L1)
- Relieves immunosuppression
- Restores antitumor activity of T cells
- Promising for cancer research
Cayman Chemical JWH 398 5CLOronaphhyl Isom 5mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Medchemexpress LLC 4-tert-Butyl-benzhyd 5mg | 62034-73-5 | 5 MG
4-(tert-butyl)-benzhydroxamic acid is a benzhydroxamic acid derivative used in bacterial quorum sensing research as a PqsR antagonist. It is supplied as a solid research reagent with high purity and is commonly used to study pyocyanin production and related virulence pathways.
- High purity: 99.5%
- Molecular weight: 193.24 g/mol
- Chemical formula: C11H15NO2
- CAS number: 62034-73-5
- Available sizes: solid quantities from 5 mg to 500 mg
- Documented resources: datasheet, certificate of analysis, and safety data sheet available
Medchemexpress LLC Mao-B-IN-30 | 82973-15-7 | 98.5% | 344.16 | 100 MG
MAO-B-IN-30 (compound IS7) is a potent, selective, and blood-brain barrier-crossing MAO-B inhibitor with IC50 values of 19.176 μM for MAO-A and 0.082 μM for MAO-B. It exhibits antiproliferative activity and is non-cytotoxic. MAO-B-IN-30 reduces levels of TNF-alpha, IL-6, and NF-kB, and shows potential for Parkinson's disease research.
- Potent, selective, and blood-brain barrier-crossing MAO-B inhibitor.
- Shows antiproliferative activity and is non-cytotoxic.
- Reduces TNF-alpha, IL-6, and NF-kB levels.
- Potential for Parkinson's disease research.
- For research use only.
Medchemexpress LLC HY-P1237A 1mg , C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) CAS:1966153-17-2 Purity:>98%
HY-P1237A 1mg C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) CAS: 1966153-17-2 C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC O-acetyl-L-serine | 5147-00-2 | MFCD00037771 | >=98.0% | 147.13 g/mol | C5H9NO4 | 25 MG
O-Acetylserine (O-acetyl-L-serine) is an endogenous metabolite and an analytical standard used in research to study sulfur assimilation and cysteine biosynthesis. It functions as a biochemical intermediate and signaling molecule that can influence expression of sulfate transporters and adenosine 5'-phosphosulfate reductase. Supplied for analytical and research applications in small, quantified amounts.
- Analytical standard suitable for biochemical and analytical research.
- Endogenous metabolite involved in cysteine biosynthesis.
- Modulates gene expression of sulfate transporters and APS reductase.
- Molecular formula C5H9NO4 and molecular weight 147.13 g/mol.
- Supplied in small, quantified mg quantities for analytical use.
Medchemexpress LLC 4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide | 1191951-57-1 | 98.1% | 5 MG
PHT-427 is a small-molecule research inhibitor that targets the pleckstrin homology (PH) domains of Akt and PDPK1 and is used to probe Akt/PDPK1 signaling in cellular and in vivo studies.
- Inhibits Akt PH domain (Ki = 2.7 μM).
- Inhibits PDPK1 PH domain (Ki = 5.2 μM).
- Molecular formula C20H31N3O2S2; molecular weight 409.61.
- High purity (98.1% by HPLC).
- CAS number 1191951-57-1.
- Typical supply: 5 mg solid.
Medchemexpress LLC FAM-DEALA-Hyp-YIPD | 99.4% | 1477.48 | 5 MG
FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1α peptide with a Kd of 180-560 nM.
- Assesses VHL binding in Fluorescence Polarization (FP) displacement assays.
- Evaluates the impact of VHL binding on degradation activity.
Medchemexpress LLC Ssk36 (TFA) | 99.3% | 1771.04 (free base) | 25 MG
ssK36 TFA is a supersubstrate peptide designed for the histone methyltransferase (SET) domain protein 2 (SETD2). It adds methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. This peptide can be methylated by SETD2 over 100 times faster than the natural substrate H3K36, making it valuable for studying the catalytic mechanism of PKMTs, particularly substrate specificity and catalytic efficiency.
- Designed for the SETD2 protein, a specific PKMT.
- Adds methyl groups to H3K36 to form H3K36me3.
- Methylated over 100 times faster than the natural substrate H3K36.
- Used to study the catalytic mechanism of protein lysine methyltransferases (PKMTs).
- Suitable for investigating substrate specificity and catalytic efficiency.
Medchemexpress LLC KWCN-41 | 2913223-17-1 | 99.8% | 307.35 | 100 MG
KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM. It specifically inhibits cell necrosis but does not inhibit apoptosis and also exhibits anti-inflammatory effects.
- Inhibits L929 cell necroptosis
- Increases viable cell numbers
- Inhibits phosphorylation of RIPK1/3 and MLKL
- Protects HT-29 and U937 cells from necroptosis
- Improves survival in inflammatory mouse model
Medchemexpress LLC HY-116807 25mg , Dihydrolipoic Acid CAS:462-20-4 Purity:>98%
HY-116807 25mg Dihydrolipoic Acid CAS: 462-20-4 Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical. Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Ropsacitinib S9676-100MG
Ropsacitinib (PF-06826647 Tyk2-IN-8 compound 10) is a selective and orally administered inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 17 nM for binding to TYK2 catalytically active JH1 domain PF-06826647 (Tyk2-IN-8 compound 10) also inhibits JAK1 and JAK2 with IC50 of 383 nM and 74 nM respectively PF-06826647 (Tyk2-IN-8 compound 10) is used in the treatment of psoriasis (PSO)
Cayman Chemical QuercetIn-7-OD-Glucopyrno 5mg
A flavonoid; has antioxidant activity in a ORAC assay and decreases tert-butyl hydroperoxide-induced ROS in L-929 cells at 0.25 and 1 UG/ml; reduces protein levels of iNOS and COX-2 in LPS-stimulated RAW 264.7 cells at 15 and 30 UG/ml; decreases angiogenesis in isolated rat aortic rings and proliferation of HUVECs but has no effect on tube formation or chemotaxis of HUVECs at 100 µM